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KMID : 0613820080180030381
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Journal of Life Science
2008 Volume.18 No. 3 p.381 ~ p.386
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Effect of Deep Sea Water on Phase I, Phase II and Ornithine Decarboxylase
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Shon Yun-Hee
Kim Mee-Kyung
Jang Jung-Sun
Jung Eun-Jung
Nam Kyung-Soo
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Abstract
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Deep sea water was tested for cancer chemopreventive activity by measuring the activities of β -naphthoflavone (β-NF)-induced cytochrome P 450 1A2 (CYP 1A2), quinone reductase (QR) and glutathione-S-transferase (GST), glutathione (GSH) levels, and ornithine decarboxylase (ODC) activity. The in vitro incubation of rat liver microsome with deep sea water (a hardness range of 100~1000 ) showed a hardness-dependent inhibition of CYP 1A2 activity. QR and GST activities were induced about 1.1~1.2 fold with the treatment of deep sea water in murine hepatoma Hepa 1clc7 cells. In addition GSH levels were increased 1.3~1.4 fold in a hardness range of 100~1000. The deep sea water showed 20.3 and 35.0% inhibition of 12-O- tetradecanoylphorbol-13-a-cetate (TPA)-induced ODC activity at hardness 800 and 1,000, respectively. Therefore, deep sea water is worth further investigation with respect to cancer chemoprevention or therapy.
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KEYWORD
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Deep sea water, cytochrome P450 1A2, quinone reductase, glutathione-S-transferase, glutathione, ornithine decarboxylase
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